Reaktion #2006483

Reaktionsgleichung

2,2 Dimethyl succinic anhydride

4-amino-2-trifluoromethyl-benzonitrile

5-amino-2-cyanobenzotrifluoride

→

4-(3,3-dimethyl-2,5-dioxo-1-pyrrolidinyl)-2-trifluoromethyl-benzonitrile

Reaktionsbedingungen

Vorschrift

2,2 Dimethyl succinic anhydride (2.0 g, 15.6 mmol) and 4-amino-2-trifluoromethyl-benzonitrile 1a (2.91 g, 15.6 mmol) was heated at 220° C. for 2 hrs. The resulting solid (4.59 g, 99%) was used as such in the next step. 1H NMR (400 MHz, Acetone-d6) δ: 1.44 (s, 6H), 2.84 (s, 2H), 7.97 (dd, 1H, J1=6.74 Hz, J2=1.63 Hz), 8.08 (s, 1H), 8.24 (d, 1H, J=8.32 Hz).

Quelle