Reaktion #2006430

Reaktionsgleichung

2-(6-methyl-2-pyridyl)-1-(6-(phthalimido)hexyl)imidazole

hydrazine hydrate

→

crude product

1-(6-Aminohexyl)-2-(6-methyl-2-pyridyl)imidazole

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution was cooled to room temperature
2. 2
   Filtrationsuction filtered
3. 3
   Sonstigeto remove the precipitate
4. 4
   SonstigeThe filtrate was evaporated

Vorschrift

To a solution of 2-(6-methyl-2-pyridyl)-1-(6-(phthalimido)hexyl)imidazole (4.2 g) in 50 mL EtOH was added 1.5 mL hydrazine hydrate. The resulting solution was stirred at 80° C. overnight. The solution was cooled to room temperature and suction filtered to remove the precipitate. The filtrate was evaporated to give the crude product, which was purified by a silica gel column using 5% conc. NH3H2O/CH3CN as the eluent. Yield: about 2.5 g.

Quelle