Reaktion #2006423

Reaktionsgleichung

4-vinyl-benzoic acid

benzenethiol

VAZO

→

white solid

Ausbeute 85.0%

4-(2-Thiophenyl)-ethyl Benzoic Acid

Ausbeute 85.0%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAccording to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask
2. 2
   Temperaturat reflux
3. 3
   Sonstigethe solvent was evaporated under vacuo
4. 4
   SonstigeThe solid was purified by trituration

Vorschrift

According to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask containing 4-vinyl-benzoic acid (1.0 g, 6.75 mmoles) in 10 mL of benzene (0.7 M) was added benzenethiol (797 μL, 7.76 mmoles) followed by VAZO™ (Aldrich Chemical Company, 495 mg, 2.02 mmoles). The mixture was stirred for 12 hours at reflux. The resulting solution was cooled at room temperature and the solvent was evaporated under vacuo. The solid was purified by trituration using hexane and dichloromethane to afford 1.94 g (85%) of white solid.

Quelle