Reaktion #2005689

Reaktionsgleichung

Ethyl-5-chloroisoxazole

lithium hydroxide

dioxane

→

5-chloroisoxazole-3-carboxylic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated under reduced pressure
2. 2
   Sonstigethe phases were separated
3. 3
   Extraktionthe aqueous were extracted with ethyl acetate
4. 4
   SonstigeThe organic rejoined were dried
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   Sonstigethe crude material 1.2 g (95%) was used without further purification

Vorschrift

Ethyl-5-chloroisoxazole (1.5 g; 8.54 mmol) was added to a mixture of lithium hydroxide (10 mL; 2M in water) and dioxane (10 mL). The reaction mixture was stirred vigorously at room temperature for 1 h and concentrated under reduced pressure. The crude material was reparted between ethyl acetate and HCl 1M; the phases were separated and the aqueous were extracted with ethyl acetate. The organic rejoined were dried, concentrated under reduced pressure and the crude material 1.2 g (95%) was used without further purification.

Quelle