Reaktion #2005516

Reaktionsgleichung

7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid

1-(2-bromo-ethyl)-3-methyl-benzene

potassium carbonate

1-(2-bromo-ethyl)-3-methyl-benzene

potassium carbonate

→

title compound

Ausbeute 78.3%

7-(2-m-Tolyl-ethoxy)-benzo[1,3]dioxole-5-carboxylic acid 2-m-tolyl-ethyl ester

Ausbeute 78.3%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo
2. 2
   workup.DISSOLUTIONthe residue dissolved in 200 ml of water
3. 3
   SonstigeThe organic layer was separated
4. 4
   Waschenwashed with 100 ml of a saturated aqueous sodium carbonate solution
5. 5
   Trocknendried with magnesium sulfate
6. 6
   Sonstigeevaporated

Vorschrift

2.5 g of 7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid, 6.8 g of 1-(2-bromo-ethyl)-3-methyl-benzene and 7.6 g of potassium carbonate were stirred in 100 ml of anhydrous DMF for 10 h at 80° C. Then another 1.4 g of 1-(2-bromo-ethyl)-3-methyl-benzene and 1.5 g of potassium carbonate were added and the mixture was stirred for 5 h at 90° C. The solvent was removed in vacuo and the residue dissolved in 200 ml of water and 200 ml of EA. The organic layer was separated, washed with 100 ml of a saturated aqueous sodium carbonate solution, dried with magnesium sulfate and evaporated to yield 4.5 g of the title compound.

Quelle