Reaktion #2003942

Reaktionsgleichung

2-chloro-1,1,1-trimethoxy-ethane

2-amino-4-bromophenol

2-chloro-1,1,1-trimethoxy-ethane

→

5-bromo-2-chloromethyl-benzoxazole

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred for 20 h
2. 2
   SonstigeThe reaction mixture is evaporated down
3. 3
   SonstigeThe purification

Vorschrift

1.79 mL (13.3 mmol) 2-chloro-1,1,1-trimethoxy-ethane are added dropwise at RT to a solution of 2.5 g (13.29 mmol) 2-amino-4-bromophenol in 20 mL ethanol and stirred for 48 h. Then 0.4 mL 2-chloro-1,1,1-trimethoxy-ethane are added and stirred for 20 h. The reaction mixture is evaporated down. The purification is carried out by column chromatography on silica gel (DCM/ethanol 80:1).

Quelle