Reaktion #2000680

Reaktionsgleichung

compound

2-Amino-6-mercapto-4-(methylthio)pyridine-3,5-dicarbonitrile

sodium bicarbonate

4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole

→

2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-(methylthio)pyridine-3,5-dicarbonitrile

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA solid precipitated out
2. 2
   Filtrationthis solid was filtered off with suction through a glass frit
3. 3
   Waschenwashed three times with water
4. 4
   SonstigeThe residue was dried under reduced pressure

Vorschrift

7.30 g (32.84 mmol) of the compound from Example 43A (2-amino-6-mercapto-4-(methylthio)pyridine-3,5-dicarbonitrile), 11.03 g (131.36 mmol) of sodium bicarbonate and 9.62 g (39.41 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole were combined in 150 ml of absolute DMF and stirred at room temperature for 12 h. A solid precipitated out; this solid was filtered off with suction through a glass frit and washed three times with water and twice with diethyl ether. The residue was dried under reduced pressure.

Quelle