Reaktion #1997523

Reaktionsgleichung

magnesium dioxide

1-phenyl-4-methyl-3,4-dihydroisoquinoline

→

pure yellow crystals

Ausbeute 42.5%

1-phenyl-4-methylisoquinoline

Ausbeute 42.5%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was heated
2. 2
   Temperaturat reflux for 16 hours
3. 3
   SonstigeThe magnesium dioxide was removed by vacuum filtration
4. 4
   Waschenwashed with methylene chloride
5. 5
   SonstigeEvaporation of the solvent

Vorschrift

To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.

Quelle