Reaktion #1994258

Reaktionsgleichung

10-(biphenyl-4-yl)-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine

Ausbeute 77.7%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe resultant solution was washed with distilled water
2. 2
   ExtraktionThen, an organic layer was extracted
3. 3
   Trocknendried with sodium sulfate so as
4. 4
   Sonstigeto remove the solvent
5. 5
   SonstigeThe residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20))

Vorschrift

The obtained 10-(biphenyl-4-yl)-9,10-dihydroacridine (15.3 g, 45.9 mmol) was added with chloroform (500 ml), and then with bromosuccinimide (9.8 g, 55.1 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20)) to obtain 10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine compound (white solid, 14.7 g, yield 77%).

Quelle