Reaktion #1994230

Reaktionsgleichung

methylphenidate HCl

→

Methylphenidate

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONslowly adding 1,306 g of AMBERLITE™
2. 2
   workup.ADDITIONThe dispersion was mixed for 4 hours and upon completion
3. 3
   Sonstigebefore decanting the supernatant
4. 4
   SonstigeThe wet resin complex was then dried in a VWR™ convection oven
5. 5
   workup.ADDITIONEUDRAGIT™ NE-30D of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
6. 6
   Sonstigeto form a uniform mass
7. 7
   Sonstigeagain dried at 50° C. in a VWR™ convection oven to the moisture content around 4-6%
8. 8
   SonstigeThe dried granules were then milled through a 40 mesh screen

Vorschrift

The Methylphenidate Resin Complex was prepared by first dissolving 500 g of methylphenidate HCl in 8 liters of purified water, and then slowly adding 1,306 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 20-30%. EUDRAGIT™ NE-30D of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was then passed through a 10 mesh screen and again dried at 50° C. in a VWR™ convection oven to the moisture content around 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

Quelle