Reaktion #1993064

Reaktionsgleichung

3,4-dihydro-1,3-dimethyl-6-(4-ethoxycarbonylmethoxy-3-methoxyphenyl)-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone

sodium hydroxide

→

3,4-dihydro-6-(4-carboxymethoxy-3-methoxyphenyl)-1,3-dimethyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter removal of the solvent
2. 2
   workup.DISSOLUTIONthe residue was dissolved in water (5 ml)
3. 3
   Extraktionextracted with chloroform
4. 4
   TrocknenThe organic layer was dried over sodium sulfate
5. 5
   Sonstigeevaporated
6. 6
   Sonstigetriturated in diisopropyl ether

Vorschrift

To a solution of 3,4-dihydro-1,3-dimethyl-6-(4-ethoxycarbonylmethoxy-3-methoxyphenyl)-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone as obtained in Example 16 (0.67 g) in methanol (4 ml) was added 1N aqueous sodium hydroxide (2.38 ml) and the mixture was stirred at ambient temperature for 2 hours. After removal of the solvent, the residue was dissolved in water (5 ml), neutralized with 1-Nhydrochloric acid and extracted with chloroform. The organic layer was dried over sodium sulfate, evaporated, and triturated in diisopropyl ether to give 3,4-dihydro-6-(4-carboxymethoxy-3-methoxyphenyl)-1,3-dimethyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone (0.47 g).

Quelle