Reaktion #1991700

Reaktionsgleichung

benzaldehyde

difluoromethyl phenyl sulfone

sodium hydroxide

→

2,2-difluoro-1-phenyl-2-phenylsulfonylethanol

Ausbeute 90.3%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGVigorous stirring
2. 2
   workup.WAITwas continued for four hours
3. 3
   workup.ADDITIONthe resulting mixture was poured into 20 mL of 1N HCL
4. 4
   ExtraktionExtraction of the aqueous mixture with three 10 mL portions of dichloromethane
5. 5
   Sonstigedrying
6. 6
   Einengen(MgSO4), and concentration in vacuo of the organic layers
7. 7
   Sonstigegave a residue which
8. 8
   Sonstigewas purified by preparative TLC (two 2 mm silica gel plates eluted with dichloromethane)

Vorschrift

A mixture of 100 mg (0.52 mmol) of difluoromethyl phenyl sulfone, 1.0 mL of dichloromethane, 1.0 mL of 50% aqueous sodium hydroxide and 20 mg (0.050 mmol) of Aliquat 336 was stirred vigorously for 10 minutes and treated with a solution of 0.16 mL (1.6 mmol) of benzaldehyde in 0.5 mL of dichloromethane. Vigorous stirring was continued for four hours and the resulting mixture was poured into 20 mL of 1N HCL. Extraction of the aqueous mixture with three 10 mL portions of dichloromethane followed by combination, drying (MgSO4), and concentration in vacuo of the organic layers gave a residue which was purified by preparative TLC (two 2 mm silica gel plates eluted with dichloromethane), affording 140 mg (90% yield) of 2,2-difluoro-1-phenyl-2-phenylsulfonylethanol as a solid. Crystallization from toluene provided an analytical sample: mp 77°-79° C.; IR (neat) 3503, 3064, 2922, 1447, 1335, 1312, 1197, 1154, 1113, 1089, 996, 738, 715, 698, 685, 585, 558, cm-1 1H NMR (CDCl3) δ3.54 (broad s, 1H), 5.54 (dd, 1H, JHF =21, 3 Hz), 7.20-8.10 (m, 10H); 19F NMR (CDCl3, relative to CFCl3) -106.4 ppm (dd, 1F, JFF =238 Hz, JHF =3Hz), -121.6 ppm (dd, 1F, JFF =238 Hz, JHF =21 Hz); mass spectrum (70 eV) m/e relative intensity) 298 (8, M+), 156(18), 109(31), 107(100), 79(30), 78(18), 77(56), 51(20). Anal. Calcd. for C14H12F2O3S:C, 56.37; H, 4.06. Found: C, 56.58; H, 4.08.

Quelle