Reaktion #1988

Reaktionsgleichung

K2CO3

compound

2-benzyl-4,6-dioxooctahydropyrrolo[3.4-c]pyridine

benzyl bromide

→

title compound

Ausbeute 111.4%

2,5-dibenzyl-4,6-dioxooctahydropyrrolo[3.4-c]pyridine

Ausbeute 111.4%

Lösungsmittel

DMF

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwas washed with water and brine
2. 2
   Sonstigedried
3. 3
   Einengenconcentrated

Vorschrift

To a mixture of 905 mg of K2CO3 and 400 mg of the compound from step 457b in 5 mL of DMF was added 308 mg of benzyl bromide, and the reaction mixture was stirred at room temperature under N2 for 6.5 hours. The mixture was diluted with ethyl acetate, which was washed with water and brine, dried and concentrated to give 610 mg of the title compound.

Quelle