Reaktion #1985

Reaktionsgleichung

compound

1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid

LAH

→

title compound

Ausbeute 99.9%

1-benzyl-3-trifluoromethylpyrrolidine-3-methanol

Ausbeute 99.9%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water
2. 2
   workup.STIRRINGthe mixture was stirred for 1 hour
3. 3
   Filtrationfiltered
4. 4
   SonstigeThe filtrate was dried
5. 5
   Einengenconcentrated

Vorschrift

The compound from step 456a (2.32 g) was dissolved in 60 mL of dry THF, 1.12 eq of LAH (1N in dry THF) was added, and the reaction was stirred under N2 for 3 hours. The reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water, then the mixture was stirred for 1 hour and filtered. The filtrate was dried and concentrated to give 2.2 g of the title compound.

Quelle