Reaktion #1984923

Reaktionsgleichung

( 6R )

(6S)2,6 diamino-4,5,6,7-tetrahydro-benzothiazole

(6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine

2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

→

(6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe products of purification processes
2. 2
   workup.WAITa much smaller (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine peak can be seen at about 9 minutes
3. 3
   SonstigeThe area of these peaks provides an estimated composition for the mixture which
4. 4
   Sonstigepurification
5. 5
   workup.WAITIn FIG. 3B, a large (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole peak is observed at about 6 minutes
6. 6
   SonstigeResults for each exemplary reaction
7. 7
   Sonstigeare provided in Table 3

Vorschrift

The products of purification processes were then analyzed by HPLC for chemical and chiral purity. FIG. 3A shows an exemplary HPLC trace starting material. In FIG. 4A, a large (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine peak can be observed at about 6 minutes and a much smaller (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine peak can be seen at about 9 minutes. The area of these peaks provides an estimated composition for the mixture which is shown in the table below the trace, and shows the mixture as containing about 90.2% (6R) and 8.8% (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine. FIG. 3B shows an exemplary trace of the 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole product following purification. In FIG. 3B, a large (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole peak is observed at about 6 minutes, and no (6S)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole peak is observed. It is additionally of note that several other minor peaks are also reduced or eliminated in the product trace, and the table below the trace indicates that (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine makes up 99.9% of the product solution which is within the limits of analytical detectability. Results for each exemplary reaction are provided in Table 3:

Quelle