Reaktion #1984918

Reaktionsgleichung

n-propyl sulfonate

n-propyl sulfonate

2,6 diamino-4,5,6,7-tetrahydro-benzothiazole

→

2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto form a solution
2. 2
   Sonstigethe reaction
3. 3
   Temperaturunder heating for an additional period of time
4. 4
   Sonstigefor example, about 1 hour to about 12 hours
5. 5
   Sonstigein a reaction step
6. 6
   workup.ADDITIONIn certain embodiments, the reaction mixture may be mixed by, for example
7. 7
   workup.STIRRINGmay be continually stirred from the heating step to the reaction step
8. 8
   Sonstigethe reaction step
9. 9
   Temperaturthe reaction mixture may be cooled

Vorschrift

In some embodiments, step one of the process may include the additional steps of heating a diamine to form a solution or melt in a heating step and adding the n-propyl halide or n-propyl sulfonate slowly over a period of time from, for example, about 0.5 hours to about 5 hours, in an additional step. In other embodiments, after the n-propyl halide or n-propyl sulfonate has been completely added to the 2,6 diamino-4,5,6,7-tetrahydro-benzothiazole, the reaction may continue under heating for an additional period of time ranging from, for example, about 1 hour to about 12 hours, in a reaction step. In certain embodiments, the reaction mixture may be mixed by, for example, stirring for one or more of the steps above or the reaction mixture may be continually stirred from the heating step to the reaction step. Following the reaction step, the reaction mixture may be cooled and the 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole may be isolated and purified.

Quelle