Reaktion #1983077

Reaktionsgleichung

HCl

pramipexole

HCl

pramipexole

→

pramipexole dihydrochloride

Lösungsmittel

isopropyl acetate

IPAC

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeHCl (gas) may be bubbled into the slurry for about 1 hour
2. 2
   Filtrationafter which the mixture may be filtered
3. 3
   Waschenwashed with IPAC
4. 4
   Sonstigedried under vacuum at room temperature

Vorschrift

An alternate method for conversion of the sulfonate or halide salts of pramipexole to an HCl salt involves the use of a concentrated solution of HCl and isopropyl acetate (IPAC). A sulfonate or halide salt of pramipexole may be taken up in IPAC and cooled to 15° C. HCl (gas) may be bubbled into the slurry for about 1 hour, after which the mixture may be filtered, washed with IPAC and dried under vacuum at room temperature to afford a pramipexole dihydrochloride salt. A detailed example of this synthesis may be found in Example 9.

Quelle