Reaktion #1981896

Reaktionsgleichung

tert-butyl[2-(2-acetylhydrazino)-2-oxoethyl]carbamate

Lawesson's reagent

→

title compound

Ausbeute 79.3%

tert-butyl[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]carbamate

Ausbeute 79.3%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction mixture
2. 2
   Temperaturwas heated
3. 3
   Temperaturto reflux for 3 hr
4. 4
   EinengenThe reaction was concentrated
5. 5
   Sonstigechromatographed on silica gel eluting with a gradient solvent mixture of AcOEt & dichloromethane

Vorschrift

To a 37.5 mL THF solution of tert-butyl[2-(2-acetylhydrazino)-2-oxoethyl]carbamate (496 mg, 2.15 mmol) was added Lawesson's reagent (900 mg, 2.23 mmol). The resulting reaction mixture was heated to reflux for 3 hr. The reaction was concentrated and chromatographed on silica gel eluting with a gradient solvent mixture of AcOEt & dichloromethane to give the title compound as white crystalline solid (391 mg).

Quelle