Reaktion #1978177

Reaktionsgleichung

(3-amino-phenyl)-methanesulfonamide

4-chloro-6-(2-methoxyphenyl)-pyrimidin-2-ylamine

→

{3-[2-amino-6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-methanesulfonamide

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated in vacuo
2. 2
   SonstigeThe resulting residue was purified by column chromatography on silica gel

Vorschrift

A mixture of (3-amino-phenyl)-methanesulfonamide (0.16 g, 0.85 mmol) and 4-chloro-6-(2-methoxyphenyl)-pyrimidin-2-ylamine (0.2 g, 0.85 mmol) in DMF (5 mL) was stirred at 80-90° C. till the reaction completion (TLC control), then evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel yielding {3-[2-amino-6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-methanesulfonamide

Quelle