Reaktion #1973962

Reaktionsgleichung

product

methyl 3-tert-butyl-2-hydroxy-5-nitrobenzoate

toluene

acrylic acid

acrylic acid

→

crude title compound

3-(3-tert-butyl-4-methoxy-5-(methoxycarbonyl)phenylamino) propanoic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThis mixture was heated
2. 2
   Temperaturto reflux
3. 3
   workup.ADDITIONadded every 3 h
4. 4
   TemperaturThe mixture was then refluxed for 24 h
5. 5
   TemperaturThe mixture was then cooled
6. 6
   Einengenconcentrated under vacuum to dryness

Vorschrift

The product from Example 5, Part C (16.44 g, 69.3 mmol) was dissolved in toluene (200 mL). This mixture was heated to reflux and acrylic acid added over time (1 mL of acrylic acid added every 3 h, 5.23 mL total, 76.2 mmol). The mixture was then refluxed for 24 h. The mixture was then cooled and concentrated under vacuum to dryness to yield an oil as the crude title compound that was used directly in the next reaction.

Quelle