Reaktion #1973952

ord-1ebcb65b71f84c4b8ee1ed306232cb28

Reaktionsgleichung

O=C(Cn1ncnn1)c1ccccc1Cl
1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-2-yl)ethan-1-one
O=C(Cn1cnnn1)c1ccccc1Cl
1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-1-yl)ethan-1-one
O[C@@H](Cn1ncnn1)c1ccccc1Cl
(R)-1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-2-yl)ethan-1-ol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe same procedure as in Preparation Example 3
  2. 2
    Sonstigeprepared in Preparation Example 2

Vorschrift

The same procedure as in Preparation Example 3 was repeated, with the exception that 1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-2-yl)ethan-1-one, prepared in Preparation Example 2, was used instead of 1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-1-yl)ethan-1-one, to afford (R)-1-(2-chlorophenyl)-2-(1,2,3,4-tetrazol-2-yl)ethan-1-ol (hereinafter referred to as “2N alcohol”). The conversion rate and optical purity of the product are given in Table 1, below.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08501436B2uspto-grants-2013_08