Reaktion #1973941

Reaktionsgleichung

NaHCO3

ethyl acetate

1,3-butane diol

o-(trifluoromethyl)benzenesulfonyl chloride

→

desired product

Ausbeute 84.0%

3-Hydroxybutyl 2-(trifluoromethyl)benzenesulfonate

Ausbeute 84.0%

Lösungsmittel

CH2Cl2

—

hexanes

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGwas stirred at rt for 45 min
2. 2
   ExtraktionThe organics were extracted with CH2Cl2 (150 mL)
3. 3
   Waschenwashed with 0.5 M HCl (2×80 mL) and saturated aqueous NaCl (1×50 mL)
4. 4
   TrocknenThe organics were dried over Na2SO4
5. 5
   Einengenconcentrated
6. 6
   Sonstigeto give a crude mixture

Vorschrift

To a solution of 1,3-butane diol (2.18 g, 24 mmol) and TEA (1.64 g, 16 mmol) in CH2Cl2 (15 mL) at 0° C. was added o-(trifluoromethyl)benzenesulfonyl chloride (2 g, 8 mmol) dissolved in CH2Cl2 (20 mL). The solution was stirred at 0° C. for 2 h. Saturated aqueous NaHCO3 (15 mL) was added to the solution and mixture was stirred at rt for 45 min. The organics were extracted with CH2Cl2 (150 mL) and washed with 0.5 M HCl (2×80 mL) and saturated aqueous NaCl (1×50 mL). The organics were dried over Na2SO4 and concentrated to give a crude mixture. Silica gel chromatography (50% ethyl acetate in hexanes) yielded the desired product (2 g, 84%). 1H NMR (400 MHz CDCl3) δ 8.23 (m, 1H), 7.92 (m, 1H), 7.74 (m, 2H), 4.34 (m, 1H), 4.24 (m, 1H), 3.95 (m, 1H), 1.89 (m, 1H), 1.73 (m, 1H), 1.20 (d, 3H, J=6.3 Hz). Anal. Calcd. For C11H13F3O4S: C, 44.29; H, 4.39. Found: C, 44.29; H, 4.28.

Quelle