Reaktion #1970276

Reaktionsgleichung

HCl

10.1

1-(4-(Tetrahydropyran-2-yloxy)phenyl)ethanone

ammonium carbonate

ethanol

potassium cyanide

→

10.2

Ausbeute 65.0%

(R,S)-4-Methyl-4-(4-(tetrahydropyran-2-yloxy)phenyl)-2,5-dioxoimidazolidine

Ausbeute 65.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter a short time, a clear solution was formed
2. 2
   workup.WAITto stand at room temperature overnight
3. 3
   workup.STIRRINGstirring
4. 4
   workup.WAITwas then continued at 60° C. for 6 hours
5. 5
   workup.STIRRINGthe mixture was stirred with ice-
6. 6
   Temperaturcooling for 2 h
7. 7
   FiltrationThe precipitate was filtered off with suction
8. 8
   Waschenwashed with water
9. 9
   Trocknendried over phosphorus pentoxide in a desiccator

Vorschrift

11.01 g (50 mmol) of 10.1 and 42.3 g (440 mmol) of ammonium carbonate were suspended in 200 ml of 50% strength ethanol. 4.23 g (65 mmol) of potassium cyanide were added thereto. The mixture was stirred at 50 to 60° C. for 5 hours. After a short time, a clear solution was formed. The mixture was allowed to stand at room temperature overnight and stirring was then continued at 60° C. for 6 hours. Using 6 N HCl, the pH was adjusted to 6.3 and the mixture was stirred with ice-cooling for 2 h. The precipitate was filtered off with suction, washed with water and dried over phosphorus pentoxide in a desiccator. 9.5 g (65%) of 10.2 were obtained.

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