Reaktion #1969491

Reaktionsgleichung

(4-acetylamino-phenoxy)-acetic acid ethyl ester

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

hydrochloric acid

→

60

Ausbeute 77.6%

(4-Amino-phenoxy)acetic acid HCl

Ausbeute 77.6%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
2. 2
   Filtrationfiltered hot
3. 3
   Filtrationfiltered
4. 4
   Sonstigedried

Vorschrift

A mixture (4-acetylamino-phenoxy)-acetic acid ethyl ester 59 (375 grams, 1.582 mmol), in concentrated hydrochloric acid (9.36 liters) was refluxed for 12 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 60 (250 grams, 77.6%) as a wheat colored powder. The melting point was found to be 224-226° C. The structure was confirmed with NMR. IHNMR (D2O) δ 4.68 (s, 2H, OCH2), 3.65 (s, 3H, ester), 7.0 (d, 2H, Ar), 7.30 (d, 2H, Ar.

Quelle