Reaktion #1966290

Reaktionsgleichung

Ethyl phenylmethyl (2-fluoro-4-nitrophenyl)propanedioate

ammonium formate

→

title compound

Ausbeute 60.3%

Ethyl (4-amino-2-fluorophenyl)acetate

Ausbeute 60.3%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added under argon
2. 2
   TemperaturThe reaction mixture was refluxed for 3 hours
3. 3
   Temperaturcooled
4. 4
   Filtrationfiltered
5. 5
   SonstigeEvaporated
6. 6
   Sonstigepurified by chromatography on silica gel eluting with ethyl acetate/hexane (1:1)

Vorschrift

Ethyl phenylmethyl (2-fluoro-4-nitrophenyl)propanedioate (3.86 g, 10.6 mmol) dissolved in ethanol, was treated with ammonium formate (6.7 g, 10.6 mmol) and palladium on carbon 10% paste (380 mg) was added under argon. The reaction mixture was refluxed for 3 hours, cooled and filtered. Evaporated and purified by chromatography on silica gel eluting with ethyl acetate/hexane (1:1) to give the title compound as a yellow oil (1.26 g). LC/MS: Rt=2.10, [MH]+ 198.

Quelle