Reaktion #1962519

Reaktionsgleichung

(3SR,4SR)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidine

(RS)-4,5-dimethyl-4,5,6,7-tetrahydro-thiazolo[5.4-c]pyridine-2-carboxylic acid

HATU

→

(3SR,4SR)-5-Chloro-thiophene-2-carboxylic acid-[4-methoxy-1-{(4RS)-4,5-dimethyl-4,5,6,7-tetrahydro-thiazolo[5.4-c]pyridine-2-carbonyl}-pyrrolidin-3-yl]-amide

Reaktionsbedingungen

Vorschrift

Prepared analogously to Example 1b from (3SR,4SR)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidine and (RS)-4,5-dimethyl-4,5,6,7-tetrahydro-thiazolo[5.4-c]pyridine-2-carboxylic acid (prepared analogously to WO2004058728) with HATU as coupling reagent.

Quelle