Reaktion #1962470

Reaktionsgleichung

1-menthyl acetoacetate

→

(3S)-1-menthyl 3-hydroxybutyrate

Ausbeute 98.4%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction at 70° C. for 5.5 hours under a hydrogen pressure of 4 MPa
2. 2
   SonstigeThe thus obtained reaction solution
3. 3
   Sonstigewas subjected to evaporation of the solvent
4. 4
   workup.DISTILLATIONdistilled under a reduced pressure (121° C./170 Pa)

Vorschrift

144.2 g (0.60 mol) of 1-menthyl acetoacetate, 98.8 mg (12.0 μmol) of a catalyst [{RuCl((S)-SEGPHOS)}2(μ-Cl)3][NH2Me2] and 75 ml of methanol were put into a 500 ml capacity autoclave and allowed to undergo the reaction at 70° C. for 5.5 hours under a hydrogen pressure of 4 MPa. The thus obtained reaction solution was subjected to evaporation of the solvent and then distilled under a reduced pressure (121° C./170 Pa) to obtain 143.1 g (yield 98.4%) of the (3S)-1-menthyl 3-hydroxybutyrate of interest as a colorless oily substance.

Quelle