Reaktion #1960494

Reaktionsgleichung

hydrochloric acid

7,8-difluoro-2-pentyl-6-[1-(4-propylcyclohexyl)prop-2-ynyloxy]chroman

potassium fluoride

water

→

5,6-difluoro-3-pentyl-8-(4-propylcyclohexyl)-1,2,3,8-tetrahydropyrano[3,2-f]chromene

Lösungsmittel

N,N-diethylaniline

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   ExtraktionThe batch is extracted with MTBE
3. 3
   Waschenthe organic phase is washed with saturated sodium chloride solution
4. 4
   SonstigeThe solution is dried
5. 5
   Sonstigeevaporated to dryness
6. 6
   SonstigeThe crude product is purified by column chromatography (SiO2, 1-chlorobutane:pentane=4:1)

Vorschrift

9.7 g (23.2 mmol) of 7,8-difluoro-2-pentyl-6-[1-(4-propylcyclohexyl)prop-2-ynyloxy]chroman are heated at 200° C. for 6 h together with 2.7 g (46.5 mmol) of potassium fluoride in 75 ml of N,N-diethylaniline. After cooling, water is added, and the mixture is acidified using 25% hydrochloric acid. The batch is extracted with MTBE, and the organic phase is washed with saturated sodium chloride solution. The solution is dried using sodium sulfate and evaporated to dryness. The crude product is purified by column chromatography (SiO2, 1-chlorobutane:pentane=4:1), giving 5,6-difluoro-3-pentyl-8-(4-propylcyclohexyl)-1,2,3,8-tetrahydropyrano[3,2-f]chromene as a pale-brown oil.

Quelle