Reaktion #1959835

Reaktionsgleichung

7-Methoxy-3-nitroquinolin-4-ol

ammonium hydroxide

hydrochloric acid

→

3-amino-7-methoxyquinolin-4-ol hydrochloride

Lösungsmittel

methanol

diethyl ether

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   EinengenThe filtrate was concentrated under vacuum
3. 3
   Sonstigeto provide a green solid
4. 4
   SonstigeThe resulting precipitate was isolated by filtration
5. 5
   Sonstigedried

Vorschrift

7-Methoxy-3-nitroquinolin-4-ol (4.5 g, 20.4 mmol), methanol (250 mL), ammonium hydroxide (5 mL) and palladium on carbon (400 mg of 10%) were combined. The mixture was placed on a Parr apparatus under a hydrogen atmosphere at 40 psi (2.8 Kg/cm2) for 2 hrs. The reaction mixture was filtered. The filtrate was concentrated under vacuum to provide a green solid. This material was dissolved in methanol (20 mL) and then 1 N hydrochloric acid in diethyl ether (75 mL) was added. The resulting precipitate was isolated by filtration and dried to provide 2.6 g of 3-amino-7-methoxyquinolin-4-ol hydrochloride as a pink solid.

Quelle