Reaktion #1957

ord-6be519bfa24b404b82af4b0e9d174bb5

Reaktionsgleichung

Cc1cc(Cl)c(F)cn1
4-Chloro-5-fluoro-2-picoline
CC(=O)OF
acetyl hypofluorite
→
Cc1ncc(F)c(Cl)c1F
title compound
Cc1ncc(F)c(Cl)c1F
4-Chloro-3,5-difluoro-2-picoline

Edukte

Cc1cc(Cl)c(F)cn1
4-Chloro-5-fluoro-2-picoline
CC(=O)OF
acetyl hypofluorite

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

4-Chloro-5-fluoro-2-picoline is treated with 1.1 equivalents of acetyl hypofluorite as described by O. Lerman, et al. J Org Chem, 49: 806-813 (1984) to afford the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05726182uspto-grants-1998_03