Reaktion #1955145

Reaktionsgleichung

4-fluorobenzenesulfonic 2-(cyclopropanecarbonylamino)benzo-thiazol-6-yl ester

4-fluorobenzenesulfonic acid 2-(cyclopropanecarbonylamino)-benzothiazol-6-yl ester

N,N-diisopropyl-ethane-1,2-diamine

→

4-(2-diisopropylaminoethylamino)benzenesulfonic 2-(cyclopropanecarbonylamino)benzothiazol-6-yl ester

Lösungsmittel

NMP

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude reaction product
2. 2
   Sonstigeis purified by preparative LC/MS (basic medium (pH 9))
3. 3
   Sonstigeto give
4. 4
   Trocknenafter freeze-drying 66 mg of 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic 2-(cyclopropanecarbonyl-amino)benzothiazol-6-yl ester (beige-colored solid)

Vorschrift

A solution of 4-fluorobenzenesulfonic 2-(cyclopropanecarbonylamino)benzo-thiazol-6-yl ester (example 7) (100 mg, 255 μmol) and N,N-diisopropyl-ethane-1,2-diamine (147 mg, 1.02 mmol) in 2 ml of NMP is heated at 110° C. by microwave for 10 minutes. The crude reaction product is purified by preparative LC/MS (basic medium (pH 9)) to give after freeze-drying 66 mg of 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic 2-(cyclopropanecarbonyl-amino)benzothiazol-6-yl ester (beige-colored solid).

Quelle