Reaktion #1955138

Reaktionsgleichung

4-fluorobenzenesulfonic 2-[(piperidine-4-carbonyl)amino]benzo-thiazol-6-yl ester

intermediate 4

4-fluorobenzenesulfonic 2-[(piperidine-4-carbonyl)amino]benzo-thiazol-6-yl ester

4-(4-pyrid-3-yl-imidazol-1-yl)butylamine

NMP

→

4-(2-hydroxy-2-methylpropylamino)benzene-sulfonic acid 2-[(piperidine-4-carbonyl)amino]benzothiazol-6-yl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude reaction product
2. 2
   Sonstigeis purified by preparative LC/MS (basic medium (pH 9))
3. 3
   Sonstigeto give
4. 4
   Trocknenafter freeze-drying 21 mg of 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic 2-(cyclo-propanecarbonylamino)benzothiazol-6-yl ester (pale yellow solid)

Vorschrift

A solution of 4-fluorobenzenesulfonic 2-[(piperidine-4-carbonyl)amino]benzo-thiazol-6-yl ester (intermediate 4) (50 mg, 0.114 mmol) and of 4-(4-pyrid-3-yl-imidazol-1-yl)butylamine (40.93 mg, 0.459 mmol) in 0.5 ml of NMP is heated at 130° C. by microwave for 5 minutes. The crude reaction product is purified by preparative LC/MS (basic medium (pH 9)) to give after freeze-drying 21 mg of 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic 2-(cyclo-propanecarbonylamino)benzothiazol-6-yl ester (pale yellow solid).

Quelle