Reaktion #1955

Reaktionsgleichung

water

4-chloro-5-fluoro-2-picoline

product

4-Chloro-5-fluoro-2-picoline

t-butylhypochlorite

→

title compound

3,4-Dichloro-5-fluoro-2-picoline

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe resultant aqueous mixture is extracted with methylene chloride
2. 2
   TrocknenThe organic solution is dried over anhydrous magnesium sulfate
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   workup.DISTILLATIONdistilled

Vorschrift

To 0.87 g (6 mmol) of 4-chloro-5-fluoro-2-picoline, the product of Example 66, in 20 mL of chloroform cooled to -45° C., is added 0.75 mL of t-butylhypochlorite. The reaction mixture is stirred at -45° C. for 2 hours and at 0° C. for 2 hours. The reaction mixture is then poured into water and the resultant aqueous mixture is extracted with methylene chloride. The organic solution is dried over anhydrous magnesium sulfate, filtered, concentrated under reduced pressure and distilled to afford the title compound.

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