Reaktion #1951057

ord-8541ab0cf72e46a0bf0a27a401fe5c55

Reaktionsgleichung

C[Si](C)(C)Br
Bromotrimethylsilane
COP(=O)(Cc1ccc(F)cc1)OC
(4-fluoro-benzyl)-phosphonic acid dimethyl ester
→
C[Si](C)(C)OP(=O)(Cc1ccc(F)cc1)O[Si](C)(C)C
(4-fluoro-benzyl) phosphonic acid bis(trimethylsilyl) ester

Edukte

C[Si](C)(C)Br
Bromotrimethylsilane
COP(=O)(Cc1ccc(F)cc1)OC
(4-fluoro-benzyl)-phosphonic acid dimethyl ester

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
0°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturto warm to ambient temperature
  2. 2
    workup.STIRRINGstirred for an additional hour
  3. 3
    Einengenconcentrated by rotary evaporation
  4. 4
    Sonstigeto remove volatiles

Vorschrift

Bromotrimethylsilane (6.0 mL, 45.4 mmol) was added dropwise to (4-fluoro-benzyl)-phosphonic acid dimethyl ester (4.57 g, 20.95 mmol) and stirred in a reaction flask chilled to 0° C. The resulting solution was allowed to warm to ambient temperature and stirred for an additional hour, then concentrated by rotary evaporation to remove volatiles yielding crude (4-fluoro-benzyl) phosphonic acid bis(trimethylsilyl) ester which was used without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07625880B2uspto-grants-2009_12