Reaktion #1949696

Reaktionsgleichung

phloroglucinol

ethyl 2-(4-chlorobenzyl)-acetoacetate

HCl

→

3-(4-Chlorobenzyl)-5,7-dihydroxy-4-methyl-2H-1-benzopyran-2-one

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas kept at that temperature overnight
2. 2
   SonstigeSolvent was evaporated
3. 3
   Sonstigethe precipitate triturated with water

Vorschrift

A solution of phloroglucinol (1.57 g) and ethyl 2-(4-chlorobenzyl)-acetoacetate (3.18 g) in ethanol (25 ml) was treated with dry HCl at 0° C. for 1.5 hours and the solution was kept at that temperature overnight. Solvent was evaporated and the precipitate triturated with water. Yield 3.87 g (98%). Melting point 270-278° C.

Quelle