Reaktion #1946889

ord-451df6bf59164eb3a4eaa2b594d21be1

Reaktionsgleichung

COc1ccc(C(=O)Nc2ccccc2)cc1N
3-amino-4-methoxy-N-phenyl-benzamide
NS(=O)(=O)c1ccc(N=C=S)cc1
4-isothiocyanatobenzenesulfonamide
→
COc1ccc(C(=O)Nc2ccccc2)cc1NC(=S)Nc1ccc(S(N)(=O)=O)cc1
product
Ausbeute 47.0%
COc1ccc(C(=O)Nc2ccccc2)cc1NC(=S)Nc1ccc(S(N)(=O)=O)cc1
4-Methoxy-N-phenyl-3-[3-(4-sulfamoyl-phenyl)-thioureido]-benzamide
Ausbeute 47.0%

Edukte

COc1ccc(C(=O)Nc2ccccc2)cc1N
3-amino-4-methoxy-N-phenyl-benzamide
NS(=O)(=O)c1ccc(N=C=S)cc1
4-isothiocyanatobenzenesulfonamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to the procedure described for Example 60 using 3-amino-4-methoxy-N-phenyl-benzamide (0.974 g, 4.01 mmol) and 4-isothiocyanatobenzenesulfonamide (0.858 g, 4.00 mmol) to afford the product (0.858 g); m.p. 193-195° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06528528B2uspto-grants-2003_03