Reaktion #1946560

Reaktionsgleichung

chloroacetic acid

N,N-di-n-butyl-N′-(3-methoxybenzoyl)thiourea

compound 1-24

N,N-di-n-butyl-N′-(3-methoxybenzoyl)thiourea

sodium hydroxide

→

2-Dibutylamino-4-(3-methoxyphenyl)thiazole

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas prepared, to which
2. 2
   Temperaturheated on a steam bath for 23 hrs
3. 3
   Temperaturcooled
4. 4
   ExtraktionThe mixture was extracted with methylene chloride
5. 5
   Waschenthe extracts were washed with water
6. 6
   Trocknendried over magnesium sulfate
7. 7
   Einengenconcentrated
8. 8
   Sonstigeto crystallize on standing
9. 9
   Sonstigewas used without further purification

Vorschrift

A mixture of 114.95 g (356.5 mmol) of N,N-di-n-butyl-N′-(3-methoxybenzoyl)thiourea (compound 1-24), 31.37 g (784.2 mmol) of sodium hydroxide, and 350 ml of water was prepared, to which was added 40.42 g (427.8 mmol) of chloroacetic acid. The mixture was stirred and heated on a steam bath for 23 hrs, then cooled. The mixture was extracted with methylene chloride, and the extracts were washed with water, dried over magnesium sulfate, and concentrated. The oily residue began to crystallize on standing. The yield of thiazole was 100.8 g and was used without further purification.

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