Reaktion #1946546

Reaktionsgleichung

water

4-methacrylamidosalicylic acid

acetic anhydride

→

O-acetyl-4-methacrylamidosalicylic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITfor an additional 6 hours at room temperature
2. 2
   workup.ADDITIONThe reaction mixture is then poured into 800 g
3. 3
   SonstigeThe solid product precipitates from solution
4. 4
   Filtrationis collected by filtration
5. 5
   Sonstigeair dried at room temperature
6. 6
   Sonstigeto afford A-4-MASA in quantitative yield

Vorschrift

A few drops of concentrated sulfuric acid is added to a stirring solution of 35.0 g of 4-methacrylamidosalicylic acid (prepared according to Example 1) in 350 mL of acetic anhydride at 0° C. The solution is stirred for 60 minutes at 0° C. and then for an additional 6 hours at room temperature. The reaction mixture is then poured into 800 g of cold deionized water. The solid product precipitates from solution, and is collected by filtration. The product is then air dried at room temperature to afford A-4-MASA in quantitative yield.

Quelle