Reaktion #1946544

Reaktionsgleichung

N-Bromosuccinimide

benzoyl peroxide

p-Toluene boronic acid

neopentyl glycol

→

p-bromomethyl phenyl boronic acid-neopentyl ester

Lösungsmittel

cyclohexane

cyclohexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturat reflux for 1.5 hours
3. 3
   Temperaturthe solution was heated
4. 4
   Temperaturat reflux for additional 2 hours
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated
7. 7
   Sonstigeto give

Vorschrift

p-Toluene boronic acid (750 mg.) and neopentyl glycol (600 mg.) were dissolved in 50 ml cyclohexane and heated at reflux for 1.5 hours. N-Bromosuccinimide (1.15 g.), benzoyl peroxide (25 mg.) and 150 ml cyclohexane were added and the solution was heated at reflux for additional 2 hours. The solution was cooled to room temperature, filtered and evaporated to give a mixture of 8 and 8a (total of 1.3 g, ˜1:1 ratio), the yield of 8=47%.

Quelle