Reaktion #1946103

Reaktionsgleichung

4-(tert-butoxycarbonyl)-hexahydro-2-methyl-1H-1,4-diazepine

hexahydro-2-methyl-1H-1,4-diazepine

5-chlorosulfonyl-4-methylisoquinoline

→

objective compound

Ausbeute 15.2%

Hexahydro-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine hydrochloride

Ausbeute 15.2%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprepared
2. 2
   Sonstigesynthesized in accordance with J

Vorschrift

Using 1.07 g of 4-(tert-butoxycarbonyl)-hexahydro-2-methyl-1H-1,4-diazepine prepared by protecting the 4-position of hexahydro-2-methyl-1H-1,4-diazepine (2.8 g) synthesized in accordance with J. Med. Chem., 1990, 33, 142 and 1.21 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.27 g of the objective compound (white crystals).

Quelle