Reaktion #1945923

ord-59775554d6814fd98ec09ecf30a4ed47

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC(c2ccc(O)cc2)C(OCc2ccc3ccccc3c2)C1
tert-butyl (3RS,4RS)-4-(4-hydroxy-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate
O=C=Nc1ccccn1
2-pyridyl isocyanate
→
CC(C)(C)OC(=O)N1CCC(c2ccc(OC(=O)Nc3ccccn3)cc2)C(OCc2ccc3ccccc3c2)C1
tert-butyl (3RS,4RS)-3-(naphthalen-2-ylmethoxy)-4-[4-(pyridin-2-ylcarbamoyloxy)-phenyl]-piperidine-1-carboxylate

Edukte

CC(C)(C)OC(=O)N1CCC(c2ccc(O)cc2)C(OCc2ccc3ccccc3c2)C1
tert-butyl (3RS,4RS)-4-(4-hydroxy-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate
O=C=Nc1ccccn1
2-pyridyl isocyanate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

(ff) In an analogous manner to that described in Example 24(m), by reacting tert-butyl (3RS,4RS)-4-(4-hydroxy-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate with 2-pyridyl isocyanate there was obtained tert-butyl (3RS,4RS)-3-(naphthalen-2-ylmethoxy)-4-[4-(pyridin-2-ylcarbamoyloxy)-phenyl]-piperidine-1-carboxylate as a white solid; MS: 554 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06150526uspto-grants-2000_11