Reaktion #1940986

Reaktionsgleichung

tert-butyl 2-(4-bromophenyl)propan-2-ylcarbamate

bis(pinacolato)diboron

9-bromo-8-methoxythieno[2,3-c]quinolin-4(5H)-one

→

desired product

Ausbeute 52.6%

tert-Butyl 2-[4-(8-Methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl]propan-2-ylcarbamate

Ausbeute 52.6%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the crude boronic ester which

Vorschrift

Following General Procedure E, tert-butyl 2-(4-bromophenyl)propan-2-ylcarbamate (160 mg, 0.50 mmol) was reacted with bis(pinacolato)diboron (140 mg, 0.55 mmol) to afford the crude boronic ester which was reacted with 9-bromo-8-methoxythieno[2,3-c]quinolin-4(5H)-one (140 mg, 0.45 mmol) to afford the desired product (110 mg, 47%) as a brown solid: ESI MS m/z 465 [C26H28N2O4S+H]+.

Quelle