Reaktion #1940367

Reaktionsgleichung

6-chloro-pyridine-3-carbaldehyde

1-methylpiperazine-2-one hydrochloride

→

4-(6-chloro-pyridin-3-ylmethyl)-1-methyl-piperazin-2-one

Ausbeute 84.1%

Reaktionsbedingungen

Vorschrift

Following General Method B, 6-chloro-pyridine-3-carbaldehyde (500 mg, 3.532 mmol) and 1-methylpiperazine-2-one hydrochloride (559 mg, 3.709 mmol) gave 4-(6-chloro-pyridin-3-ylmethyl)-1-methyl-piperazin-2-one (712 mg, 84%) [following SiO2 chromatography, eluting with 0-10% MeOH/dichloromethane]. MS (ESI) m/z 240.1 (M+H)+

Quelle