Reaktion #1938530

Reaktionsgleichung

7-nitro-2-(pyridin-2-yl)-1H-indole

ethanol

→

title compound

Ausbeute 85.1%

2-(Pyridin-2-yl)-1H-indole-7-amine

Ausbeute 85.1%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationPalladium-carbon was filtered off
2. 2
   Einengenthe filtrate was concentrated

Vorschrift

A mixture of 7-nitro-2-(pyridin-2-yl)-1H-indole (0.47 g), 10% palladium-carbon (50% water, 0.05 g), ethanol (4 mL) and tetrahydrofuran (10 mL) was stirred at room temperature overnight under a hydrogen atmosphere. Palladium-carbon was filtered off, and the filtrate was concentrated. The residue was subjected to silica gel column chromatography and the title compound (0.35 g, yield 85%) was obtained as pale-yellow crystals from a fraction eluted with ethyl acetate-hexane (1:1, volume ratio). melting point 165-166° C.

Quelle