Reaktion #1938448

Reaktionsgleichung

4-(2-methyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)benzaldehyde

2-piperidine-4-yl-3H-imidazo[4,5-c]pyridine hydrochloride salt

NaBH(OAc)3

→

desired compound

Ausbeute 33.7%

5-{4-[4-(3H-imidazo[4,5-c]pyridin-2-yl)-piperidin-1-ylmethyl]-phenyl}-2-methyl-6-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine

Ausbeute 33.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigea half, and seven and a half hours (two equivalents each)
2. 2
   SonstigeThe solvents were evaporated
3. 3
   Sonstigethe usual workup and purification

Vorschrift

200 mg (0.64 mmol) 4-(2-methyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)benzaldehyde and 181 mg (0.76 mmol) 2-piperidine-4-yl-3H-imidazo[4,5-c]pyridine hydrochloride salt were treated as described in example 2.0. Additional NaBH(OAc)3 has been added after one, two, three, four and a half, five and a half, and seven and a half hours (two equivalents each). The solvents were evaporated and the usual workup and purification yields 108 mg of the desired compound.

Quelle