Reaktion #1933952

Reaktionsgleichung

water

3-((3-bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride

2-chloro-benzothiazole

DIEA

→

N-(3-((3-bromopyridin-2-yl)oxy)cyclobutyl)benzo[d]thiazol-2-amine

Ausbeute 60.0%

Lösungsmittel

NMP

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with EtOAc (40 mL)
2. 2
   Waschenwashed with brine
3. 3
   Trocknendried over Na2SO4
4. 4
   EinengenThe organic layers were concentrated
5. 5
   Sonstigepurified by column chromatography

Vorschrift

A mixture of 3-((3-bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride (242 mg, 1 mmol), 2-chloro-benzothiazole (169 mg, 1 mmol) and DIEA (286 mg, 2 mmol) in NMP (10 mL) was heated to 180° C. for 2 hours in microwave. The reaction mixture was added water, extracted with EtOAc (40 mL), washed with brine and dried over Na2SO4. The organic layers were concentrated and purified by column chromatography to give N-(3-((3-bromopyridin-2-yl)oxy)cyclobutyl)benzo[d]thiazol-2-amine (225 mg, 0.6 mmol, yield 60%). ESI-MS (M+1): 376 calc. for C16H14BrN3OS 375.

Quelle