Reaktion #1933167

ord-85a664d895b54808ac142fd6f2d799e5

Reaktionsgleichung

CC1(n2cnc3c(Cl)cnnc32)CC1
4-chloro-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine
CCS(=O)(=O)c1ccc(-c2cc(B3OC(C)(C)C(C)(C)O3)ccc2F)cc1
2-(4′-ethylsulfonyl-6-fluorobiphenyl-3-yl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane
→
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3(C)CC3)ccc2F)cc1
title compound
Ausbeute 32.0%
CCS(=O)(=O)c1ccc(-c2cc(-c3cnnc4c3ncn4C3(C)CC3)ccc2F)cc1
4-[4′-(Ethylsulfonyl)-6-fluorobiphenyl-3-yl]-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine
Ausbeute 32.0%

Edukte

CC1(n2cnc3c(Cl)cnnc32)CC1
4-chloro-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine
CCS(=O)(=O)c1ccc(-c2cc(B3OC(C)(C)C(C)(C)O3)ccc2F)cc1
2-(4′-ethylsulfonyl-6-fluorobiphenyl-3-yl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to the method described for Example 26 using 4-chloro-7-(1-methylcyclopropyl)-7H-imidazo[4,5-c]pyridazine (Preparation 97) and 2-(4′-ethylsulfonyl-6-fluorobiphenyl-3-yl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (Preparation 48) to afford the title compound as an off white solid in 32% yield, 20 mg

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08952008B2uspto-grants-2015_02