Reaktion #1931685

Reaktionsgleichung

Water

Compound 17a

2-(3-pyrazolyl)pyridine

3,4-difluoro-nitrobenzene

potassium carbonate

→

product 18a

Ausbeute 93.4%

2-(1-(2-fluoro-4-nitrophenyl)-3-pyrazolyl)pyridine

Ausbeute 93.4%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was reacted at 100° C. for 4 hours
2. 2
   SonstigeAfter completion of the reaction
3. 3
   Sonstigeresulting in a substantial amount of precipitate
4. 4
   FiltrationThen, the precipitate was suction-filtered
5. 5
   Sonstigethe filter cake was recrystallized with acetone

Vorschrift

Compound 17a (1 g, 6.9 mmol) obtained from the aforesaid process and 3,4-difluoro-nitrobenzene (0.74 mL) were dissolved in N,N-dimethylformamide (20 mL), and then anhydrous potassium carbonate (1.9 g) was added thereto. The mixture was reacted at 100° C. for 4 hours. After completion of the reaction, the reactant mixture was cooled to room temperature. Water was added to the mixture, resulting in a substantial amount of precipitate. Then, the precipitate was suction-filtered, and the filter cake was recrystallized with acetone to get the product 18a as a white powder (1.7 g), with a yield of 93.4%.

Quelle