Reaktion #1931684

Reaktionsgleichung

Compound 16a

(Z)-3-(dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one

hydrazine hydrate

→

product 17a

Ausbeute 97.3%

2-(3-pyrazolyl)pyridine

Ausbeute 97.3%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereacted at 60° C. for 0.5 hour
2. 2
   Sonstigethe solvent was removed in vacuum

Vorschrift

Compound 16a (1 g, 6.2 mmol) obtained from the aforesaid process and hydrazine hydrate (2 mL) were dissolved in ethanol (3.3 mL), and reacted at 60° C. for 0.5 hour. Then, the mixture was cooled to room temperature, and then the solvent was removed in vacuum to afford the product 17a (874.7 mg) as a faint yellow solid, with a yield of 97.3%.

Quelle