Reaktion #1929496

Reaktionsgleichung

1-BOC-4-piperidinone

2-methoxyethylamine

Sodium borohydride

→

4-(2-methoxy-ethylamino)-piperidine-1-carboxylic acid tert-butyl ester

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was removed in vacuo
2. 2
   workup.ADDITIONthe residue was diluted with DCM
3. 3
   Waschenwashed with brine
4. 4
   Trocknendried (MgSO4)
5. 5
   Sonstigethe solvent removed in vacuo
6. 6
   SonstigeThe residue was purified

Vorschrift

Amine preparation: 1-BOC-4-piperidinone (2.00 g) and 2-methoxyethylamine (872 μL) were stirred together in MeOH (20 mL) at room temperature overnight. Sodium borohydride (760 mg) was then added portionwise and the reaction mixture was allowed to stir further at ambient temperature. After 16 h, the solvent was removed in vacuo, the residue was diluted with DCM, washed with brine, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 4-(2-methoxy-ethylamino)-piperidine-1-carboxylic acid tert-butyl ester as a colourless oil (1.69 g).

Quelle